The atmospheric results of the Adriatic Sea and Coast (AdriSC) climate simulation (1987–2017) are evaluated against available observational datasets in the Adriatic region. Generally, the AdriSC model performs better than regional climate models that have resolutions that are 4 times more coarse, except concerning summer temperatures, which are systematically underestimated. High-resolution climate models may thus provide new insights about the local impacts of global warming in the Adriatic.